Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

The antidiabetic effect of Hunteria umbellata extracts (aqueous and methanol) on hematological, lipid profile biochemical parameters in streptozotocin-induced diabetes female wistar rats was studied. phytochemical screening the seed determined using standard chemical methods. Twenty five (25) weighing between 117g 170g were shared into (5) groups animals per group for physiological studies. All treatment administered 500 mg/kg body weight H. extracts. Group 1: normal control, 2: negative or diabetic 3: metformin + streptozotocin (STZ), 4: aqueous extract STZ 5: methanol STZ. Diabetes induced with 55mg/kg (STZ). Quantitative reviewed presence secondary metabolites such as, saponins, phytate, oxalate, anthraquinones, Cyanogenic glycoside; where phenols alkaloids recorded highest concentrations both hypoglycaemic studies revealed significant (p<0.005) reduction fasting blood glucose levels experimental 5 compared to moderate 3. 4 increase rats. haematological not (p>0.05) all groups. significance (p<0.05) amount high density lipoproteins (HDL), total cholesterol (CHOL), triglyceride (TRIG) low (LDL) while CHOL within safe limit. possesses potentials managements conventional drug (metformin).